How Long Does THC-O Stay In Your System?

Easily, one of the most exciting cannabinoids on today’s hemp market is THC-O.  This cannabinoid promises to be 3x as powerful as delta 9 THC in terms of its psychoactive properties, almost guaranteeing a significant high that can really give you your money’s worth, so to speak.  THC-O is now available in all kinds of product forms, and countless hemp enthusiasts enjoy the compound regularly because its properties are so uniquely gratifying.

But, whenever it comes to THC compounds such as THC-O Acetate, people are gonna wonder how long these psychoactives last in the body before they’re fully cleared.  This is especially the case among people who get drug-tested, such as those whose employments depend on testing negative.

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How Long Do the Effects of THC-O Acetate Typically Last in Our System for?

It’s important to consider how long the effects of THC-O can actually be felt in the body, which is different from how long it takes for the cannabinoid to actually leave the body.  After the effects have worn off and you’re no longer high, the cannabinoid is still getting broken down by enzymes so that it can be eliminated completely, mainly through the urine. 

THC-O-acetate (THC-O) is a cannabinoid produced by taking THC’s raw precursor compound called, “tetrahydrocannabinolic acid (THCA)”, and then synthesizing it in a laboratory to make it more potent than delta 9 THC.  Because of this, the ‘high’ is extremely strong compared to delta-8 and delta-10, as well as, of course, delta-9.  

So, once you take THC-O-acetate, how long will you actually feel the effects for?  


We mainly determine this based on the delivery method that was taken – that is, the method through which it’s absorbed int the body, whether that be ingestion, inhalation, etc.  Each delivery method allows the cannabinoid to absorb at a unique rate, and this influences how long the effects are felt.  Other factors that matter are how much of the product was consumed, and the user’s tolerance to the cannabinoid’s effects.

  • Inhalable Products (Vapes, Dabs, Flower): Products that involve inhaling the cannabinoid, such as vape cartridges, vape pens, flower, and dabs (concentrates), absorb the most quickly into the body, and the effects are therefore the shortest – about 1-2 hours in most cases.
  • Ingestible Products (Edibles, Capsules): If you’re consuming THC-O in the form of a product that’s ingested, whether that be a gummy, capsule, beverage, etc., the effects are going to last for the longest period of time since the cannabinoid is absorbed the most slowly.  Most people say that they feel the effects for about 8 or so hours.
  • Sublingual Products (Tinctures): Tinctures are absorbed sublingually (below the tongue), absorbing at a medium rate.  Overall, people report feeling the effects of THC-O for about 4 to 6 hours, depending on the formula’s milligram strengths.

Time It Takes For THC-O To Leave Our System?

Like we said before, the fact that you no longer feel THC-O-acetate’s high doesn’t mean that the cannabinoid has left the body.  In fact, it can remain there for a quite a while.  Cannabinoid are no different from other substances, including alcohol and prescription medications, in that long after we’re done experiencing their properties, they’re still present in varying amounts in the body waiting to get fully metabolized.

THC-O-acetate typically remains in your system roughly 2 to 25 days, with taking into account the many factors that can influence how much THC-O has accumulated in the body, such as frequency of usage, metabolism and when it was last taken.  

  • After about 30 minutes of feeling the cannabinoid’s effects, half of it has been metabolized
  • Followed then, by another 25% 30-min. later.  
  • It’s the 25% that’s left which can take far longer to break down, since the metabolization process slows at this point.

THC-O Acetate for Drug-Testing Purposes

The bottom line is that if you have recently taken THC-O and it’s still metabolizing in your body, this could have implications in a drug test, depending on the type of drug test you’re being administered.  Urine tests are the most popular, but there are actually a number of different kinds of tests used in different environments.

Method #1: Urine Tests: Urine-based testing is the most popular and is used by employers as well as probation officers.  It’s easy to administer, accurate and cheap.  It looks for THC-COOH, an enzyme that breaks down all THC compounds, in a person’s urine, which can be detected for up to several weeks following the last usage.

Method #2: Saliva Tests: A saliva-based test is usually used by law enforcement, most often to determine whether or not a person is driving under the influence.  It only shows results based on whether or not a THC compound has been consumed within the last 10 hours.


Method #3: Blood Tests: A blood test is usually administered in a medical environment such as a hospital, since it only shows whether or not a person is actively high on a psychoactive substance.  For a person to be intoxicated, the compound must be present in the blood.

Method #4: Hair Tests: Hair strand tests are most commonly used for autopsy reports, and they are extremely expensive.  Trace amounts of substances may be found in a person’s hair, but only about 90 days after the last usage.

Method #5: Perspiration Tests: A perspiration test involves the application of a patch that is applied to a person’s skin, since THC-COOH may be sweated out.  This is an invasive and expensive testing method that is usually only used by clinical researchers.

How Long THC-O Could Normally Last in the Body For? 

There are a lot of aspects that influence how long it takes until THC-O is fully metabolized and cleared out of the body, which we said earlier.  This is why there’s no exact length of time during which it takes for a person to completely eliminate the cannabinoid out of the system.

#1: Frequency of Use 

How frequently you’re taking THC-O makes a big difference.  

  • Taking THC-O multiple times daily can cause a traffic jam, as you’re adding more to the body than your metabolism can break down quickly enough.  
  • Taking THC-O occasionally gives the metabolism a chance to fully eliminate it between uses.

#2: Delivery Method  

The delivery method again makes a difference, like it does when it comes to the duration of the high, which we covered earlier.  It’s likely that THC-O edibles take the longest length of time to metabolize, with inhalable products metabolizing more quickly.

#3: Product Strength 

The strength of the product matters too, just like frequency of use, in the sense that taking more of it per dosage means that you’re adding more THC-O to the amount that the metabolism is already working hard trying to clear.  This can extend the amount of time needed before THC-O has fully been eliminated.


#4: Your Metabolism

Some people have faster metabolisms than others, and so they metabolize THC-O at a faster rate.  A fast metabolism can result from genetics, as well as health factors like exercise, diet and water consumption.

#5: When You Last Took THC-O

The last time you took THC-O matters as well.  For instances:

  • If it has been months since you last consumed THC-O, you’re in the clear.
  • If you’ve consumed it a couple of days ago, THC-O is still going to be in your system.

#6: Product Quality 

Some THC-O products are not giving you as much of the cannabinoid as advertised – for instance, products that are expired, or products made using inferior extraction methods that damage the compound.  This means that you’ll have less THC-O in your body than you thought you did, which will let it metabolize more quickly.

How Long After Using THC-O is it Safe to Take Any Type of Medication (Prescription or Non-Prescription)?

We know that cannabinoids suppress CYP3A4 enzyme, a metabolite that breaks down a lot of common medications.  This means that THC-O-acetate could prevent many popular drugs from metabolizing, which would lead to them building up in the bloodstream to potentially harmful levels.

No research has shown the specific effect of THC-O on CYP3A4, which’s why we cannot offer specific information about how long to wait before taking a medication dosage.  This is a critical conversation to have with your doctor, who can offer personalized advice based on their knowledge of your medical circumstances.

The Bottom Line: It All Depends On How Long THC-O Lasts

When it comes to THC-O-acetate, or any cannabinoid for that matter, there are a number of variables that all have a significant effect on how long it can take until your system is fully clear of the compound.  At the same time, there’s no proven way to get a cannabinoid to leave your body more quickly.  What this means is that if you’re wondering about this because you have a drug test coming up, it may be wise to simply abstain from THC-O altogether until after the test is complete, just to be on the safe side.

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